SYNTHESIS AND PHOTOCYTOTOXICITY OF SOME NEW SUBSTITUTED PHTHALOCYANINES
| Autor: | Clifford C. Leznoff, David M. Drew, I. Rosenthal, Steven Vigh, E. Ben-Hur, P. I. Svirskaya, Shafrira Greenberg |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
chemistry.chemical_classification
Radiation-Sensitizing Agents Indoles Cell Survival Iodide Cationic polymerization Infrared spectroscopy chemistry.chemical_element Pigments Biological General Medicine Zinc Isoindoles Cleavage (embryo) Biochemistry Cell Line Phthalonitrile Structure-Activity Relationship chemistry.chemical_compound chemistry Polymer chemistry Phthalocyanine Animals Organic chemistry Boron tribromide Physical and Theoretical Chemistry |
| Zdroj: | Photochemistry and Photobiology. 49:279-284 |
| ISSN: | 1751-1097 0031-8655 |
| DOI: | 10.1111/j.1751-1097.1989.tb04107.x |
| Popis: | Some new, ring-substituted phthalocyanines have been synthesized and underwent preliminary testing for photodynamic activity using the colony forming ability of Chinese hamster cells in culture as an endpoint. Using 4-(3-N,N-diethylaminopropyl)phthalonitrile as a precursor, the previously unknown metal-free 2,9,16,23-tetra-(3-N,N-diethylaminopropyl)phthalocyanine was prepared and converted to its zinc (II) and its cationic water-soluble 2,9,16,23-tetramethylammonium zinc (II) iodide derivatives. Other new phthalocyanine derivatives tested, include a 2,9,16,23-tetra(2-hydroxymethyl-2-methylbutoxy)phthalocyaninato zinc (II) and 2,3,9,10,16,17,23,24-octahydroxyphthalocyaninato zinc (II) derivatives. Boron tribromide cleavage of the newly prepared and fully characterized 2,3,9,10,16,17,23,24-octamethoxyphthalocyanine gave the unstable metal-free octahydroxyphthalocyanine, which could only be characterized by ultraviolet-visible, NMR and IR spectroscopy. |
| Databáze: | OpenAIRE |
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