Hyper-ovulation, endometriosis, and hyperplasia associated with tamoxifen exposure in Swiss albino mice
| Autor: | Muhammad Farooq Khan, Badr Aldahmash, Iman Ali Alanazy, Doaa Mohamed El-Nagar, Khalid Elfaki Ibrahim, Ahmed Rady, Jameel Al-Tamimi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class media_common.quotation_subject Hormone disruptors Endometriosis Uterus 02 engineering and technology 010501 environmental sciences 01 natural sciences Internal medicine medicine skin and connective tissue diseases lcsh:Science (General) Ovulation 0105 earth and related environmental sciences media_common Multidisciplinary business.industry Hyperplasia 021001 nanoscience & nanotechnology medicine.disease Liver enzymes Tamoxifen Endocrinology medicine.anatomical_structure Caspase-3 Estrogen Toxicity 0210 nano-technology business hormones hormone substitutes and hormone antagonists medicine.drug Hormone lcsh:Q1-390 |
| Zdroj: | Journal of King Saud University: Science, Vol 32, Iss 7, Pp 3026-3031 (2020) |
| ISSN: | 1018-3647 |
| Popis: | The available literature on the safety profile of tamoxifen in human patients and in experimental animals is mostly contradictory. The present study was therefore, designed to understand the safety profile of tamoxifen using Swiss albino mice. Swiss albino mice of age 13 weeks were orally administered tamoxifen (35 mg/kg/day) for 80 days. The breast, liver, and ovaries were used to evaluate the toxicity of tamoxifen in these organs using histopathology by H& E staining, the organ indices, estimation of liver enzymes, sex hormones, and antioxidant enzymes were compared with control mice group. The histopathological profiles indicated that breasts of the treated mice were not affected; however, it caused major damage to the liver, uterus, and ovaries. Tamoxifen also induced a moderate level of apoptosis by elevating the level of caspase-3 in the liver, uterus, and ovaries of the treated mice. The estrogen and progesterone levels were also significantly reduced. Tamoxifen induced hyper ovulation in treated mice group which has never been reported before. These data suggest that hepatotoxicity and hyper ovulation associated with tamoxifen could not be overruled and hence an alternate hormone disruptors other than tamoxifen should be investigated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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