Cefetamet pivoxil in the treatment of uncomplicated gonorrhea
| Autor: | Margot Kissling, Marinette Zappelini, Carlos Enrique Borges, Luiz Felipe de Araujo Vieiralves, Ricardo Lucena, Jean-Marie Kanga, P. Hohl |
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| Rok vydání: | 1994 |
| Předmět: |
Microbiology (medical)
Sexually transmitted disease Adult Male medicine.medical_specialty Spectinomycin Adolescent Gonorrhea Internal medicine medicine Cefetamet Humans Prospective Studies Adverse effect Aged business.industry Ceftizoxime General Medicine Amoxicillin Middle Aged medicine.disease Surgery Probenecid Infectious Diseases Tolerability Female business medicine.drug |
| Zdroj: | Diagnostic microbiology and infectious disease. 19(2) |
| ISSN: | 0732-8893 |
| Popis: | We studied the efficacy and safety of cefetamet pivoxil (CAT), an oral aminothiazolyl cephalosporin, in a series of open, comparative multicenter studies in 207 women (four study centers) with uncomplicated gonorrhea, and summarized and pooled the results with those of earlier open dose-finding trials (360 men; six study centers). We compared single-dose treatment regimen of CAT--over the range of 400-1500 mg--with spectinomycin, thiamphenicol, ampicillin, or amoxicillin plus probenecid. The overall cure rates were 100% in 88 women treated with 1500 mg CAT and in 137 men treated with 1200 or 1500 mg CAT, 98% (114 of 116 men) in those treated with 800 or 1000 mg CAT, and 93% (42 of 45 men) in those treated with 400 or 500 mg CAT; the composite cure rate of the comparators was 97%. The tolerability of CAT (n = 428) compared favorably (1.8% adverse events) with that of the standard drugs (n = 139) (4.3% adverse events). Single-dose treatment with 1500 mg CAT is effective and safe in adults with uncomplicated gonorrhea. |
| Databáze: | OpenAIRE |
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