Serum Glutamine Levels as a Potential Diagnostic Biomarker in Sepsis following Surgery for Peritonitis
| Autor: | Chung-Ho Hsieh, Ting-Shuo Huang, Chun Ju Yang, Yu-Chiau Shyu, Kang-Chung Yang, Ruey-Hwa Lu, Shinsheng Yuan, Tung-Liang Lee |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Physiology Glutamine chemistry.chemical_element Peritonitis Sepsis 03 medical and health sciences Severity assessment Postoperative Complications Physiology (medical) Medicine Diagnostic biomarker Humans Aged business.industry Emergency department Middle Aged medicine.disease Surgery 030104 developmental biology chemistry Biomarker (medicine) Female business Selenium Biomarkers |
| Zdroj: | The Chinese journal of physiology. 60(6) |
| ISSN: | 0304-4920 |
| Popis: | Few diagnostic biomarkers for sepsis after emergency peritonitis surgery are available to clinicians, and, thus, it is important to develop new biomarkers for patients undergoing this procedure. We investigated whether serum glutamine and selenium levels could be diagnostic biomarkers of sepsis in individuals recovering from emergency peritonitis surgery. From February 2012 to March 2013, patients who had peritonitis diagnosed at the emergency department and underwent emergency surgery were screened for eligibility. Serum glutamine and selenium levels were obtained at pre-operative, post-operative and recovery time points. The average level of pre-operation serum glutamine was significantly different from that on the recovery day (0.317 ± 0.168 vs. 0.532 ± 0.155 mM, P < 0.001); moreover, serum glutamine levels were unaffected by surgery. Selenium levels were significantly lower on the day of surgery than they were at recovery (106.6 ± 36.39 vs. 130.68 ± 56.98 ng/mL, P = 0.013); no significant difference was found between pre-operation and recovery selenium levels. Unlike selenium, glutamine could be a sepsis biomarker for individuals with peritonitis. We recommend including glutamine as a biomarker for sepsis severity assessment in addition to the commonly used clinical indicators. |
| Databáze: | OpenAIRE |
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