Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes
| Autor: | Hannes Lans, Martijn S. Luijsterburg, Orlando D. Schärer, Katja Apelt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
DNA Repair
DNA damage DNA repair PTM XPC DDB2 Review Cellular and Molecular Neuroscience chemistry.chemical_compound Nucleosome Animals Humans Molecular Biology Pharmacology Global genome nucleotide-excision repair biology Cell Biology Chromatin Cell biology Nucleosomes Nucleotide excision repair Histone DNA Repair Enzymes chemistry biology.protein Molecular Medicine Post-translational modification Protein Processing Post-Translational DNA DNA Damage |
| Zdroj: | Cellular and Molecular Life Sciences Cellular and Molecular Life Sciences, 78(24), 7925-7942. SPRINGER BASEL AG |
| Popis: | Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a barrier for DNA repair proteins to access DNA lesions buried in nucleosomal DNA. The DNA-damage sensors XPC and DDB2 recognize DNA lesions in nucleosomal DNA and initiate repair. The emerging view is that a tight interplay between XPC and DDB2 is regulated by post-translational modifications on the damage sensors themselves as well as on chromatin containing DNA lesions. The choreography between XPC and DDB2, their interconnection with post-translational modifications such as ubiquitylation, SUMOylation, methylation, poly(ADP-ribos)ylation, acetylation, and the functional links with chromatin remodelling activities regulate not only the initial recognition of DNA lesions in nucleosomes, but also the downstream recruitment and necessary displacement of GG-NER factors as repair progresses. In this review, we highlight how nucleotide excision repair leaves a mark on chromatin to enable DNA damage detection in nucleosomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|