Reduced Sertoli cell number and altered pituitary responsiveness in male lambs undernourished in utero
| Autor: | B. Kotsampasi, C. Balaskas, S. Chadio, G. Papadomichelakis |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Offspring Hypothalamic–pituitary–gonadal axis Biology Weight Gain Gonadotropin-Releasing Hormone Endocrinology Food Animals Pregnancy Internal medicine medicine Animals Testosterone Sexual Maturation Fetus Sertoli Cells Sheep Malnutrition Maternal Nutritional Physiological Phenomena General Medicine Luteinizing Hormone Sertoli cell medicine.disease medicine.anatomical_structure Animals Newborn In utero Pituitary Gland Gestation Animal Nutritional Physiological Phenomena Female Animal Science and Zoology Follicle Stimulating Hormone |
| Zdroj: | Animal Reproduction Science. 114:135-147 |
| ISSN: | 0378-4320 |
| DOI: | 10.1016/j.anireprosci.2008.08.017 |
| Popis: | The nutritional status of females during pregnancy can have profound effects on the fetus reproductive system development that could affect the reproductive potential as later as in adulthood (fetal programming). The aim of the present study was to examine the effects of maternal nutrient restriction imposed during different periods of gestation on pituitary responsiveness at different ages postnatal and on Sertoli cell number in male offspring. Pregnant ewes were fed to 100% of Metabolizable Energy and Crude Protein requirements throughout pregnancy (Control) or to 50% from 0 to 30 (R1) or from 31 to 100 days of gestation (R2). Male lambs were selected and fed to appetite throughout the study. At 2, 5.5 and 10 months of age a GnRH challenge was conducted. At slaughter (10 months) testes were removed and examined histologically. Maternal undernutrition did not affect the time of the onset of puberty, defined as the first increase in plasma testosterone concentrations > or =1 ng/ml. The LH and FSH response to GnRH challenge did not differ between groups at 2 and 5.5 months but at 10 months of age a higher (P |
| Databáze: | OpenAIRE |
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