Comparative study of macrophage response in mice after DNA immunization and infection with herpes simplex virus type 1
| Autor: | L. G. Zaitseva, O. V. Nekrasova, L. N. Shingarova, T. M. Andronova, Kobets Nv, E. F. Boldyreva, S. V. Guryanova, A. Yu. Kozlov, I. V. Kireeva, V. A. Bekhalo, E. V. Nagurskaya, Klimova Rr |
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| Rok vydání: | 2005 |
| Předmět: |
Male
viruses medicine.medical_treatment Inflammation Herpesvirus 1 Human medicine.disease_cause General Biochemistry Genetics and Molecular Biology law.invention DNA vaccination Mice Cell Movement law Vaccines DNA medicine Animals Macrophage Mice Inbred BALB C business.industry Macrophages Granulocyte-Macrophage Colony-Stimulating Factor Herpes Simplex General Medicine Virology Vaccination Herpes simplex virus Dna immunization Immunology Recombinant DNA medicine.symptom business Acetylmuramyl-Alanyl-Isoglutamine Adjuvant |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 140:716-719 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Functional activity of macrophages and intensity of T cell immune response in mice were studied after intravaginal and intraperitoneal infection with herpes simplex virus type 1 and DNA vaccination in combination with adjuvant treatment (recombinant granulocyte-macrophage colony-stimulating factor and glucosaminylmuramyl dipeptide). DNA vaccination induced a virus-specific T cell immune response with no macrophagic inflammatory reaction. Infection with herpes simplex virus type 1 was accompanied by sustained inflammation, but not by the T cell immune response. |
| Databáze: | OpenAIRE |
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