Unusually high mitochondrial alpha glycerophosphate dehydrogenase activity in rat brown adipose tissue
| Autor: | Kin-Ichi Ohkawa, Molly T. Vogt, Emmanuel Farber |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Male
medicine.medical_specialty Adipose tissue Dehydrogenase Glycerolphosphate Dehydrogenase White adipose tissue Mitochondrion Kidney Article Hydroxybutyrate Dehydrogenase Adipose Tissue Brown Glutamate Dehydrogenase Internal medicine Brown adipose tissue medicine Animals biology Histocytochemistry Succinate dehydrogenase Glutamate dehydrogenase Cell Biology Mitochondria Rats Succinate Dehydrogenase medicine.anatomical_structure Endocrinology Biochemistry Adipose Tissue Liver biology.protein Thermogenesis |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 0021-9525 |
| Popis: | Brown adipose tissue of the rat has been found to have an unusually high activity of mitohondrial alpha-glycerophosphate dehydrogenase (alpha-GPD) when assayed both by a histochemical staining procedure and by a quantitative biochemical method with isolated mitochondria. In contrast to succinic, glutamic, and beta-hydroxybutyrate dehydrogenases, all mitochondrial enzymes, the activity of alpha-GPD in brown fat was 10 times that in liver, more than 20 times that in white adipose tissue, and 9 times that in kidney. The soluble NAD-linked alpha-GPD was also higher in brown adipose tissue than in white adipose tissue, liver, or kidney, but the differences were much less marked. The possible importance of the high activity of mitochondrial alpha-GPD in the regulation of synthesis of esterified lipid and in thermogenesis in brown fat is discussed. |
| Databáze: | OpenAIRE |
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