The effects of allergen and anti-allergic drugs on murine hemopoietic cells: moving targets, unusual mechanisms, and changing paradigms
| Autor: | Maximiano Es, Pedro Xavier Elsas, Vargaftig Bb, Elsas Mi |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Hematopoietic System
Immunology Apoptosis Bone Marrow Cells medicine.disease_cause Allergic inflammation Mice Allergen Downregulation and upregulation In vivo Stress Physiological Anti-Allergic Agents medicine Immunology and Allergy Animals Humans Prostaglandin E2 Glucocorticoids Pharmacology Chemistry Cell adhesion molecule Anti-Inflammatory Agents Non-Steroidal respiratory system Allergens In vitro Up-Regulation Haematopoiesis Cytokines Cell Adhesion Molecules medicine.drug Lung Transplantation |
| Zdroj: | Current drug targets. Inflammation and allergy. 2(4) |
| ISSN: | 1568-010X |
| Popis: | We used a variety of techniques to evaluate the effects of airway allergen exposure in mice on the responses of hemopoietic cells to cytokines and drugs in vitro and in vivo. Initial studies have shown that allergen exposure of sensitized mice leads to release of circulating mediators, that induce rapid upregulation of bone-marrow responses to IL-5 and GM-CSF. This may be related to glucocorticoids, because exogenous dexamethasone has similar effects on cultured murine bone-marrow, and because stress-induced glucocorticoids, in naive or sensitized mice, have effects indistinguishable from those of allergen challenge in sensitized animals. Upregulation of eosinophil production is associated with an increased expression of alpha4 integrins, which may contribute to retention of these cells in the bone-marrow. Glucocorticoids regulate the adhesiveness, maturation and survival of eosinophils in murine bone-marrow culture, partly by counteracting the actions of Prostaglandin E2 and possibly other prostanoids. Allergen exposure of sensitized mice leads to accumulation of hemopoietic progenitors in the lungs, which differ from those in bone-marrow in growth properties and sensitivity to glucocorticoids. Lung transplantation has been used to demonstrate that the lung acts as a source of endocrine factors that promote hemopoietic cell accumulation, independently of damage caused by local allergic inflammation. |
| Databáze: | OpenAIRE |
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