A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity
| Autor: | Franck Zal, Catherine Ribault, Brendan Le Daré, Vincent Lagente, Eric Delpy, Thomas Gicquel, Pierre-Jean Ferron, Nessrine Bellamri |
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| Přispěvatelé: | Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], HEMARINA SA, This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Jonchère, Laurent |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
Amanitins animal structures [SDV]Life Sciences [q-bio] chemistry.chemical_element Toxicology Oxygen Marine worm 03 medical and health sciences Hemoglobins Extracellular medicine polycyclic compounds Humans Hepatocyte Oxygen carrier 030304 developmental biology Amanitin 0303 health sciences biology Bicyclic molecule 030302 biochemistry & molecular biology Hepatotoxicity biology.organism_classification 3. Good health [SDV] Life Sciences [q-bio] medicine.anatomical_structure chemistry Biochemistry Arenicola Hemoglobin Chemical and Drug Induced Liver Injury M101 |
| Zdroj: | Toxicon Toxicon, 2021, 200, pp.87-91. ⟨10.1016/j.toxicon.2021.07.004⟩ Toxicon, Elsevier, 2021, 200, pp.87-91. ⟨10.1016/j.toxicon.2021.07.004⟩ |
| ISSN: | 0041-0101 |
| Popis: | International audience; The amanitins (namely α- and β-amanitin) contained in certain mushrooms are bicyclic octapeptides that, when ingested, are responsible for potentially lethal hepatotoxicity. M101 is an extracellular hemoglobin extracted from the marine worm Arenicola marina. It has intrinsic Cu/Zn-SOD-like activity and is currently used as an oxygen carrier in organ preservation solutions. Our present results suggest that M101 might be effective in reducing amanitin-induced hepatotoxicity and may have potential for therapeutic development. |
| Databáze: | OpenAIRE |
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