Effect of Sucrose Feeding on Glucose Tolerance and their Relationship with Lipid Metabolism in Maternal and Fetal Livers in Rat
| Autor: | Liliana Oliveros, E. Callegari, María S. Giménez |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Very low-density lipoprotein Sucrose Physiology medicine.medical_treatment Cholesterol VLDL Gestational Age Biology Carbohydrate metabolism chemistry.chemical_compound Fetus Dietary Sucrose Pregnancy Physiology (medical) Internal medicine Dextrins medicine Animals Insulin Rats Wistar Maternal-Fetal Exchange Triglycerides reproductive and urinary physiology Glucose tolerance test medicine.diagnostic_test Cholesterol HDL Lipid metabolism Cholesterol LDL General Medicine Metabolism Glucose Tolerance Test Lipid Metabolism Rats Cholesterol Glucose Endocrinology Liver chemistry Enzyme Induction Pregnancy Animal Female Acetyl-CoA Carboxylase |
| Zdroj: | Archives of Physiology and Biochemistry. 105:640-644 |
| ISSN: | 1744-4160 1381-3455 |
| Popis: | This study was carried out to determine a possible relationship between hepatic acetyl-coenzyme A carboxylase EC 6.4.1.2 (ACC) activity in dam and fetus at 15-day and 19-day of gestation and the glucose tolerance in pregnant rats fed on the sucrose diet compared with the rats feed on the dextrin diet. Sucrose feeding increases ACC activity in livers of dam and fetus and the level of circulating LDL + VLDL cholesterol in the dam. Those findings are correlated with the high serum glucose and insulin concentrations observed in the sucrose-fed rats following oral glucose challenge in both 15-day and 19-day pregnant rats compared with the dextrin-fed rats. These results suggest that sucrose feeding to pregnant rats modified the hepatic lipid metabolism in them and in their fetus, associated with the changes in serum glucose and insulin levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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