Three-dimensional, Scaffold-Free, Autologous Chondrocyte Transplantation: A Systematic Review
| Autor: | Gianluca Vadalà, Vincenco Denaro, Moritz Riedl, Rocco Papalia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Three dimensional scaffolds
medicine.medical_specialty business.industry autologous chondrocyte transplantation Spherox Article Chondrocyte Surgery Transplantation Clinical Practice medicine.anatomical_structure Tissue engineering tissue engineering Chondrosphere Medicine Orthopedics and Sports Medicine ACT3D business |
| Zdroj: | Orthopaedic Journal of Sports Medicine |
| ISSN: | 2325-9671 |
| Popis: | Background: A 3-dimensional, scaffold-free, and completely autologous form of chondrocyte transplantation (ACT3D) has been developed and applied in clinical practice in the past decade to overcome disadvantages of previous-generation procedures. Purpose: To document and analyze the available literature on the results of ACT3D in the treatment of articular chondral lesions in the knee and hip joints. Study Design: Systematic review; Level of evidence, 4. Methods: All studies published in English addressing ACT3D were identified and included those that fulfilled the following criteria: (1) level 1 through 4 evidence, (2) measures of radiological or functional/clinical outcome, and (3) outcome related to cartilage lesions of the knee and hip joints. Results: A total of 10 studies were selected: 2 randomized controlled trials, 1 cohort study, and 7 case series. The studies revealed significant increases in patients’ subjective quality of life, satisfaction, pain reduction, and improvement in joint function at short- to medium-term follow-up. Magnetic resonance imaging-assisted examination and second-look arthroscopy showed a hyaline-like repair tissue with a high degree of defect filling and integration. Conclusion: ACT3D shows promising results in the therapy of articular cartilage defects in the knee as well as in the hip, but well-designed, long-term studies are lacking. ACT3D might have relevant advantages over common matrix-associated autologous chondrocyte transplantation products, but systematic evaluation and randomized controlled studies are crucial to verify the potential of this tissue-engineered approach. |
| Databáze: | OpenAIRE |
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