Lupus-like glomerulonephritis: an autoimmune complication of hepatitis C infection
| Autor: | Monica Srivastava, Marie Philipneri, Liliane Hobeika, David S. Brink, Mai Vo, Krista L. Lentine, Nadia Wasi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Nephrology
medicine.medical_specialty Systemic lupus erythematosus Cyclophosphamide business.industry medicine.medical_treatment Case Report Immunosuppression General Medicine Hepatitis C medicine.disease medicine.disease_cause Cryoglobulinemia Autoimmunity Liver disease Internal medicine Immunology medicine business medicine.drug |
| Zdroj: | CEN Case Reports. 1:29-33 |
| ISSN: | 2192-4449 |
| Popis: | Lupus-like glomerulnephritis in patients with negative lupus serologies and no extra-renal manifestations of lupus can create a diagnostic dilemma. We describe a 53-year-old gentleman with chronic hepatitis C virus (HCV) infection who presented with dialysis-requiring renal failure, renal histologic findings of "full-house" immunofluorescence label and tubuloreticular inclusions on electronic microscopy, but no extra-renal or laboratory signs of systemic lupus erythematosis. Attempted treatment with cyclophosphamide and corticosteroids was limited by cyclophosphamide hypersensitivity. The patient remained dialysis-dependent over 18 months of observation and did not develop extra-renal clinical or biological manifestations of lupus. Mimics of seronegative lupus with isolated renal involvement can include HCV-related autoimmunity. Treatment of acute glomerulonephritis may be similar initially, but other concerns in patients with HCV infection include excluding cryoglobulinemia, the potential impact of immunosuppression therapy on liver disease and consideration of subsequent use of antiviral therapy. Given the increasing prevalence of HCV globally, the recognition of extra-hepatic autoimmune manifestations of HCV infection will likely increase. |
| Databáze: | OpenAIRE |
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