Effect of long-term administration of a prostacyclin analogue (beraprost sodium) on myocardial fibrosis in Dahl rats
| Autor: | Akiko Fukushima, Ryou Tanaka, Aiko Soda, Yoshihisa Yamane, Yuuto Saida, Masahiko Takenaka, Nobutaka Ida, Tatsuo Kaneshige |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Heart Ventricles Vasodilator Agents Longevity Hemodynamics Prostacyclin urologic and male genital diseases Drug Administration Schedule Contractility Coronary circulation Internal medicine medicine Animals Heart Failure Rats Inbred Dahl General Veterinary business.industry Beraprost sodium Epoprostenol Fibrosis Rats medicine.anatomical_structure Orally active Heart Function Tests Cardiology Myocardial fibrosis business Cardiomyopathies hormones hormone substitutes and hormone antagonists medicine.drug Endocardium |
| Zdroj: | The Journal of veterinary medical science. 69(12) |
| ISSN: | 0916-7250 |
| Popis: | Beraprost sodium (BPS) is an orally active prostacyclin analogue. The effects of BPS on the heart, including coronary circulation improvement, myocardial and vascular protection and anti-fibrosis effect on myocardium interstitium, have previously been demonstrated. However, the effects of BPS on hemodynamics, cardiac function and myocardial contractility in patients in the hypertrophic phase have not been clarified. Therefore, in the present study, the effects of BPS under long-term administration were investigated using the hypertension model of salt-sensitive Dahl rats. Six-week-old Dahl rats were divided into three groups, an 8% high salt diet group treated with BPS (BPS group), an untreated 8% high salt diet group (HHF group) and an untreated 0.3% low salt diet group (Control group), and observations were conducted until 17 weeks of age. In the BPS and HHF groups, the survival rates after 11 weeks of high salt diet intake were 87.5% and 47.1%, respectively (p |
| Databáze: | OpenAIRE |
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