Influence of peripheral arterial disease on capillary pressure in the foot
| Autor: | Joost A van der Spruit, Sjoerd M. Lagarde, Dirk T. Ubbink, Michael J. Jacobs, Jurgen C. de Graaff |
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| Přispěvatelé: | Amsterdam Cardiovascular Sciences, Amsterdam Public Health, Surgery |
| Rok vydání: | 2003 |
| Předmět: |
Male
Capillary pressure Supine position Posture Hemodynamics Arterial Occlusive Diseases Constriction Orthostatic vital signs Laser-Doppler Flowmetry Medicine Humans Aged Peripheral Vascular Diseases business.industry Foot Microcirculation Middle Aged Intermittent claudication Vasodilation Blood pressure Anesthesia Surgery Female medicine.symptom business Cardiology and Cardiovascular Medicine Perfusion |
| Zdroj: | Journal of vascular surgery, 38(5), 1067-1074. Mosby Inc. |
| ISSN: | 0741-5214 |
| Popis: | Background: Capillary perfusion and transmural pressure are delicately regulated by microvascular constriction mechanisms, which are activated upon a change in posture. Capillary flow is known to be disturbed in patients with severe peripheral arterial disease. To date, however, the influence of this disease on capillary pressure is unknown. Methods: Capillary pressure in the nail fold of the hallux, ankle, and toe blood pressures were measured in the sitting and supine positions in 8 patients with intermittent claudication (F2), in 7 patients with rest pain and/or ischemic ulcers (F3-4), and in 12 age-matched healthy controls (F0). Red blood cell velocity, laser Doppler flux, and continuous blood pressure of the second toe were measured simultaneously. Toe, ankle, and brachial pressure were measured after the experiment in both positions. Results: Capillary pressure did not increase significantly with increasing disease severity (F0, F2, and F3-4) in supine (P =.37; medians, 17, 21, and 14 mm Hg, respectively) and sitting (P =.96; medians, 59, 60, and 60 mg Hg, respectively) positions, whereas toe systolic pressure did, both in supine (P |
| Databáze: | OpenAIRE |
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