Immunohistochemical analysis of the arterial supply and mast cells of the trigeminal ganglion
| Autor: | G Aleksandra Milosavljevic, S Jelena Boljanovic, Jelena Djokovic Dj., Aleksandar Mircic Lj., B Dejan Cetkovic, V Mila Cetkovic, B Aleksandar Malikovic, M Aleksandra Dozic, V Bojan Stimec |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Neurons
trigeminal ganglion Pathology medicine.medical_specialty QH301-705.5 business.industry immunohistochemical analysis Immunohistochemical analysis neurons mast cells microvessels General Biochemistry Genetics and Molecular Biology Trigeminal ganglion Microvessels Mast cells Medicine Immunohistochemistry Mast (botany) ddc:610 Biology (General) General Agricultural and Biological Sciences business |
| Zdroj: | Archives of Biological Sciences (2021) pp. 16-16 Archives of Biological Sciences, Vol 73, Iss 2, Pp 215-222 (2021) |
| ISSN: | 0354-4664 |
| Popis: | The aim of this study was to quantify the distribution of microvessels and mast cells in all three parts of the trigeminal ganglion (TG). Statistical analyses were applied to investigate possible micromorphological regional differences in their density. Five serially sectioned human TGs were prepared for CD34 and mast cell tryptase immunostaining. The following quantifications were performed in microscopic fields of three parts of the TG: microvessel density (MVD), mast cell density (MCD) and ganglionic cell count. The density of CD34-positive microvessels was not significantly different in any of the three observed parts of the TG. The distribution of neurons showed no significant statistical difference in three parts of the TG. There was no difference in the density of tryptase-positive mast cells within the TG, but there was an abundant presence of mast cells in the periganglionic dural and subdural tissues, a finding hitherto not reported. We can say that there is a homogenous vascular pattern within the TG which excludes local predominance in pathogenesis of trigeminal neuralgia. Second, and more important, the finding of peri-trigeminal mast cells indicates their important role in migraine pain and confirms their degranulation as the main therapeutic goal for this condition. |
| Databáze: | OpenAIRE |
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