Spatial patterns of gene expression in the olfactory bulb
| Autor: | Yasushi Okazaki, Jonathan Scolnick, Terence P. Speed, David M. Lin, John Ngai, Heather M. Marsh, Yee Hwa Yang, Vivian Peng, Yoshihide Hayashizaki, Lisa J. Brunet |
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| Rok vydání: | 2004 |
| Předmět: |
Brain Mapping
Multidisciplinary Microarray analysis techniques Gene Expression Profiling Reproducibility of Results Sensory system In situ hybridization Biological Sciences Biology Bioinformatics Olfactory Bulb Brain mapping Olfactory bulb Smell Gene expression profiling Mice nervous system Gene expression Animals Cluster Analysis Neurons Afferent Neuroscience Gene In Situ Hybridization Oligonucleotide Array Sequence Analysis |
| Zdroj: | Proceedings of the National Academy of Sciences. 101:12718-12723 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | How olfactory sensory neurons converge on spatially invariant glomeruli in the olfactory bulb is largely unknown. In one model, olfactory sensory neurons interact with spatially restricted guidance cues in the bulb that orient and guide them to their target. Identifying differentially expressed molecules in the olfactory bulb has been extremely difficult, however, hindering a molecular analysis of convergence. Here, we describe several such genes that have been identified in a screen that compiled microarray data to create a three-dimensional model of gene expression within the mouse olfactory bulb. The expression patterns of these identified genes form the basis of a nascent spatial map of differential gene expression in the bulb. |
| Databáze: | OpenAIRE |
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