Fecal microbiota transplantation as a new treatment for canine inflammatory bowel disease
| Autor: | Takahiro Teshima, Hidekazu Koyama, Yunosuke Yuchi, Hirotaka Matsumoto, Yasushi Kataoka, Ryoko Kibe, Ryohei Suzuki, Ayaka Niina |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
biology business.industry Immunology Gastroenterology Fusobacteria Disease biology.organism_classification medicine.disease Applied Microbiology and Biotechnology Microbiology Inflammatory bowel disease Pathogenesis Diarrhea Fusobacterium Internal medicine medicine Microbiome medicine.symptom business Feces Food Science |
| Zdroj: | Bioscience of microbiota, food and health. 40(2) |
| ISSN: | 2186-6953 |
| Popis: | In human medicine, fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridioides difficile infection. It has also been tested as a treatment for multiple gastrointestinal diseases, including inflammatory bowel disease (IBD). However, only a few studies have focused on the changes in the microbiome following FMT for canine IBD. Here, we performed FMT in nine dogs with IBD using the fecal matter of healthy dogs and investigated the subsequent changes in the fecal microbiome and clinical signs. In three dogs, the fecal microbiome was examined by 16S rRNA sequencing. Fusobacteria were observed at a low proportion in dogs with IBD. However, the post-FMT microbiome became diverse and showed a significant increase in Fusobacteria proportion. Fusobacterium was detected in the nine dogs by quantitative polymerase chain reaction. The proportion of Fusobacterium in the post-FMT fecal microbiome was significantly increased (p |
| Databáze: | OpenAIRE |
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