Cognitive and neurophysiological assessment of patients with minimal hepatic encephalopathy in Brazil
| Autor: | Jefferson Abrantes, Carlos Eduardo Brandão-Mello, Daniel Torres |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
Male Pediatrics Cirrhosis Cross-sectional study lcsh:Medicine Diseases Neuropsychological Tests Electroencephalography Cognition 0302 clinical medicine Psychology Young adult lcsh:Science Signs and symptoms Hepatic encephalopathy Multidisciplinary medicine.diagnostic_test Gastroenterology Brain Middle Aged Cognitive test Neurology Evoked Potentials Auditory Female 030211 gastroenterology & hepatology Brazil Adult medicine.medical_specialty Adolescent Article Young Adult 03 medical and health sciences Medical research medicine Humans Aged business.industry lcsh:R Case-control study medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Case-Control Studies Hepatic Encephalopathy lcsh:Q business Biomarkers 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Minimal hepatic encephalopathy is a syndrome caused by cirrhosis, with a broad spectrum of clinical manifestations. Its diagnosis is based on abnormal results of cognitive and neurophysiological tests, but there are no universally available criteria, especially in Brazil, where local testing standards are required. The objective of the present study was to compare the performance of the mini-mental state examination (MMSE), Rey’s auditory-verbal learning test (RAVLT), psychometric score of hepatic encephalopathy (PHES), topographic mapping of brain electrical activity (TMBEA) and long-latency auditory evoked potential (P300) in the detection of minimal hepatic encephalopathy in Brazil. From 224 patients with cirrhosis included in the global sample, 82.5% were excluded due to secondary causes responsible for cognitive or neurophysiological dysfunction. The final sample consisted of 29 cirrhotics, with predominance of A5 Child-Pugh classification, and 29 controls paired in critical variables such as age, educational level, gender, professional category, scores suggestive of mild depression, association with compensated type 2 diabetes mellitus and sociodemographic characteristics. Overall, performance on cognitive tests and TMBEA did not show a statistically significant difference. There was a marked difference in P300 latency adjusted for age, with patients with cirrhosis showing a mean of 385 ± 78 ms (median of 366.6 ms) and healthy volunteers exhibiting a mean of 346.2 ± 42.8 ms (median of 348.2 ms) (p |
| Databáze: | OpenAIRE |
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