Left-right asymmetry in BMP4 signalling pathway during chick gastrulation

Autor:	Anne-Hélène Monsoro-Burq, Nicole M. Le Douarin
Přispěvatelé:	Laboratoire d'embryologie cellulaire et moléculaire (LECM), Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)
Rok vydání:	2000
Předmět:	MESH: Signal Transduction Embryology MESH: Bone Morphogenetic Protein 7 MESH: Sequence Homology Amino Acid Bone Morphogenetic Protein 7 MESH: Bone Morphogenetic Proteins [SDV]Life Sciences [q-bio] MESH: Bone Morphogenetic Protein 4 Bone Morphogenetic Protein 2 Smad Proteins MESH: Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 Chick Embryo MESH: Amino Acid Sequence MESH: Base Sequence Mice 0302 clinical medicine Transforming Growth Factor beta MESH: Gene Expression Regulation Developmental MESH: Animals Cloning Molecular Axis Cervical Vertebra 0303 health sciences Gene Expression Regulation Developmental MESH: Bone Morphogenetic Protein Receptors Type I MESH: Chick Embryo Hedgehog signaling pathway Cell biology DNA-Binding Proteins Bone morphogenetic protein 7 medicine.anatomical_structure Bone Morphogenetic Proteins embryonic structures Signal transduction Signal Transduction MESH: Body Patterning medicine.medical_specialty DNA Complementary animal structures MESH: Trans-Activators Molecular Sequence Data Protein Serine-Threonine Kinases Biology Quail MESH: Protein-Serine-Threonine Kinases Smad1 Protein MESH: Gene Expression Profiling 03 medical and health sciences MESH: Gastrula Internal medicine MESH: Receptors Growth Factor Notochord medicine Animals Humans Receptors Growth Factor MESH: Cloning Molecular Amino Acid Sequence Autocrine signalling MESH: Mice Bone Morphogenetic Protein Receptors Type I MESH: Transforming Growth Factor beta Body Patterning 030304 developmental biology MESH: Humans MESH: Molecular Sequence Data Polarity (international relations) Base Sequence Sequence Homology Amino Acid MESH: Quail Gene Expression Profiling MESH: Smad1 Protein MESH: Smad Proteins Gastrula MESH: DNA Complementary Gastrulation Endocrinology Trans-Activators NODAL MESH: DNA-Binding Proteins 030217 neurology & neurosurgery MESH: Axis Developmental Biology
Zdroj:	Mechanisms of Development Mechanisms of Development, Elsevier, 2000, 97 (1-2), pp.105-8. ⟨10.1016/S0925-4773(00)00417-2⟩
ISSN:	0925-4773
DOI:	10.1016/s0925-4773(00)00417-2
Popis:	International audience; Determination of the left-right (L-R) axis was shown recently to implicate several genes, among which TGFbeta-related molecules such as Activin betaB, lefty1 and 2 and Nodal. We show here that Bmp4 and its signal transduction pathway partners BMPR IA and Smad1 are transiently expressed on the right side of Hensen's node, when L-R polarity is being established. Moreover, Smad1 is expressed asymmetrically in the nascent notochord. These observations suggest a role for a BMP4-dependent autocrine or paracrine mechanism during early L-R determination.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115589cd9a1f5c73420201c4e5031d75 https://doi.org/10.1016/s0925-4773(00)00417-2 Zobrazit plný text záznamu Full Text from ScienceDirect