Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation

Autor: Edwin M. Robertson, Geneviève Albouy, Nina Dolfen, Kimberly L. Chan, Richard A.E. Edden, Stephan P. Swinnen, Mareike A. Gann, Bradley R. King, Menno P. Veldman, Marco Davare, Nicolaas A.J. Puts, Dante Mantini
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
Magnetic Resonance Spectroscopy
Brain activity and meditation
Motor learning
Cognitive Neuroscience
Hippocampus
Prefrontal Cortex
Neurosciences. Biological psychiatry. Neuropsychiatry
Stimulation
Striatum
Biology
Hippocampal formation
Motor Activity
Serial Learning
Proof of Concept Study
Prefrontal cortex
050105 experimental psychology
Article
03 medical and health sciences
Young Adult
GABA
0302 clinical medicine
Basal ganglia
medicine
Connectome
Humans
0501 psychology and cognitive sciences
gamma-Aminobutyric Acid
Theta-burst stimulation
business.industry
05 social sciences
Evoked Potentials
Motor
Magnetic Resonance Imaging
Transcranial Magnetic Stimulation
Dorsolateral prefrontal cortex
medicine.anatomical_structure
Neurology
Brain stimulation
Caudate Nucleus
business
Neuroscience
030217 neurology & neurosurgery
Psychomotor Performance
RC321-571
Zdroj: NeuroImage
Gann, M A, King, B R, Dolfen, N, Veldman, M P, Chan, K L, Puts, N A J, Edden, R A E, Davare, M, Swinnen, S P, Mantini, D, Robertson, E M & Albouy, G 2021, ' Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation ', NeuroImage, vol. 237, 118158 . https://doi.org/10.1016/j.neuroimage.2021.118158
NeuroImage, Vol 237, Iss, Pp 118158-(2021)
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2021.118158
Popis: While it is widely accepted that motor sequence learning (MSL) is supported by a prefrontal-mediated interaction between hippocampal and striatal networks, it remains unknown whether the functional responses of these networks can be modulated in humans with targeted experimental interventions. The present proof-of-concept study employed a multimodal neuroimaging approach, including functional magnetic resonance (MR) imaging and MR spectroscopy, to investigate whether individually-tailored theta-burst stimulation of the dorsolateral prefrontal cortex can modulate responses in the hippocampus and the basal ganglia during motor learning. Our results indicate that while stimulation did not modulate motor performance nor task-related brain activity, it influenced connectivity patterns within hippocampo-frontal and striatal networks. Stimulation also altered the relationship between the levels of gamma-aminobutyric acid (GABA) in the stimulated prefrontal cortex and learning-related changes in both activity and connectivity in fronto-striato-hippocampal networks. This study provides the first experimental evidence, to the best of our knowledge, that brain stimulation can alter motor learning-related functional responses in the striatum and hippocampus. This work was supported by the Belgian Research Foundation Flanders (FWO; G099516N) and internal funds from KU Leuven. GA also received support from FWO (G0D7918N, G0B1419N, 1524218N) and Excellence of Science (EOS, 30446199, MEMODYN, with SPS and DM). MAG, ND and MPV received salary support from these grants. MAG is funded by a predoctoral fellowship from FWO (1141320N). Financial support for author BRK was provided by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement (703490) and a postdoctoral fellowship from FWO (132635). This study applies tools developed under National Institutes of Health (NIH) Grants R01- EB-016089, R01-023963, and P41-EB015909; RAEE also receives salary support from these grants. NAJP receives salary support from NIH Grant R00-MH-107719. EMR received salary support from the Air Force Office of Scientific Research (AFOSR, Virginia, USA; FA9550-16-1-0191).
Databáze: OpenAIRE
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