Neuronal Migration and Lamination in the Vertebrate Retina
| Autor: | Mauricio Rocha-Martins, Rana Amini, Caren Norden |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
retina mosaics Neuronal migration Review Lamination (topology) Biology lcsh:RC321-571 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lamination medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Process (anatomy) Vertebrate retina neuronal migration Retina General Neuroscience Retinal 030104 developmental biology medicine.anatomical_structure nervous system chemistry connectivity Impaired retinal function Neuron Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Neuroscience, Vol 11 (2018) Frontiers in Neuroscience Frontiers in neuroscience |
| ISSN: | 1662-453X |
| Popis: | In the retina, like in most other brain regions, developing neurons are arranged into distinct layers giving the mature tissue its stratified appearance. This process needs to be highly controlled and orchestrated, as neuronal layering defects lead to impaired retinal function. To achieve successful neuronal layering and lamination in the retina and beyond, three main developmental steps need to be executed: First, the correct type of neuron has to be generated at a precise developmental time. Second, as most retinal neurons are born away from the position at which they later function, newborn neurons have to move to their final layer within the developing tissue, a process also termed neuronal lamination. Third, these neurons need to connect to their correct synaptic partners. Here, we discuss neuronal migration and lamination in the vertebrate retina and summarize our knowledge on these aspects of retinal development. We give an overview of how lamination emerges and discuss the different modes of neuronal translocation that occur during retinogenesis and what we know about the cell biological machineries driving them. In addition, retinal mosaics and their importance for correct retinal function are examined. We close by stating the open questions and future directions in this exciting field. |
| Databáze: | OpenAIRE |
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