Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses
| Autor: | Daria Rutkowska, Ann E. Meyers, Edward P. Rybicki, Tsepo L. Tsekoa, Inga I. Hitzeroth, Martha M. O’Kennedy, Susan J. Dennis, Carina W. Lourens |
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| Přispěvatelé: | Department of Molecular and Cell Biology, Faculty of Science |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Serotype [SDV]Life Sciences [q-bio] African Horse Sickness Virus Short Report Antibodies Viral Vaccines Attenuated African Horse Sickness Virus (AHSV) Neutralization 03 medical and health sciences 0302 clinical medicine Virus-like Particles (VLPs) African Horse Sickness Tobacco Animals Horses 030212 general & internal medicine Virus Neutralization Titers lcsh:Veterinary medicine Attenuated vaccine General Veterinary biology Immunogenicity Live-attenuated Vaccines (LAV) Viral Vaccines biology.organism_classification Antibodies Neutralizing Virology 3. Good health 030104 developmental biology Recombinant vaccines AHSV Serotypes biology.protein lcsh:SF600-1100 African horse sickness Antibody |
| Zdroj: | Veterinary Research Veterinary Research, BioMed Central, 2018, 49 (1), pp.105. ⟨10.1186/s13567-018-0600-4⟩ Veterinary Research, Vol 49, Iss 1, Pp 1-6 (2018) Vet Res |
| ISSN: | 0928-4249 1297-9716 |
| DOI: | 10.1186/s13567-018-0600-4⟩ |
| Popis: | African horse sickness (AHS) is caused by multiple serotypes of the dsRNA AHSV and is a major scourge of domestic equids in Africa. While there are well established commercial live attenuated vaccines produced in South Africa, risks associated with these have encouraged attempts to develop new and safer recombinant vaccines. Previously, we reported on the immunogenicity of a plant-produced AHS serotype 5 virus-like particle (VLP) vaccine, which stimulated high titres of AHS serotype 5-specific neutralizing antibodies in guinea pigs. Here, we report a similar response to the vaccine in horses. This is the first report demonstrating the safety and immunogenicity of plant-produced AHS VLPs in horses. Electronic supplementary material The online version of this article (10.1186/s13567-018-0600-4) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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