Hereditary Congenital Goiter with Thyroglobulin Deficiency in a Breed of Goats*
| Autor: | W. F. Van Voorthuizen, J. E. Van Dijk, W. H. H. Tegelaers, A. Rijnberk, J. J. M. De Vijlder |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
endocrine system
medicine.medical_specialty Goiter endocrine system diseases medicine.medical_treatment Thyroid Gland Immunoelectrophoresis Thyroglobulin Endocrinology Internal medicine medicine Animals Inbreeding Thyroglobulin Deficiency medicine.diagnostic_test Chemistry Goats Thyroid Albumin Radioimmunoassay Iodoproteins medicine.disease Immunodiffusion Disease Models Animal medicine.anatomical_structure |
| Zdroj: | Endocrinology. 102:1214-1222 |
| ISSN: | 1945-7170 0013-7227 |
| Popis: | Hereditary congenital goiter occurring in an inbred breed of goats is reported. The goitrous goats were severely hypothyroid. Thyroglobulin-related antigens could only be detected by radioimmunoassay in amounts of 0.03% of the total protein concentration in the 105,000 x g supernate of the goitrous gland, which corresponded with 8 microgram soluble thyroglobulin-related antigens/g tissue. After treatment with digitonin, 4 microgram thyroglobulin-related antigens/g tissue could be extracted from the sediment. This means that the gland contained about 12 microgram thyroglobulin-related antigens/g tissue (normal about 100 mg/g). However, no thyroglobulin (19S) could be detected by ultracentrifugation experiments, immunodiffusion, or immunoelectrophoresis. Iodinated proteins with sedimentation constants of 3-9S were found. Among these iodinated macromolecular compounds, iodinated "albumin" and some non-hydrolysable iodinated material was found. These last mentioned components were also found in the blood, indicating a leakage from the gland. As described for comparable cases, these results indicate a defect in thyroglobulin synthesis or its regulation. |
| Databáze: | OpenAIRE |
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