Photosensitizer Loaded Nano-Graphene for Multimodality Imaging Guided Tumor Photodynamic Therapy
| Autor: | Zhuang Liu, Wei Wang, Zhe Wang, Dale O. Kiesewetter, Avinash Srivastan, Pengfei Rong, Fu Wang, Xiaoyuan Chen, Xuyi Yue, Gang Niu, Kai Yang, Liming Nie, Ashwinkumar Bhirde |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Chlorophyll
Fluorescence-lifetime imaging microscopy positron emission tomography Materials science Cell Survival medicine.medical_treatment Medicine (miscellaneous) Nanoparticle Nanotechnology Photodynamic therapy Polyethylene glycol Multimodal Imaging Polyethylene Glycols law.invention Mice chemistry.chemical_compound law Cell Line Tumor Neoplasms medicine Animals Photosensitizer Pharmacology Toxicology and Pharmaceutics (miscellaneous) Graphene oxide Photosensitizing Agents Graphene Photothermal therapy Copper Radioisotopes Microscopy Fluorescence Photochemotherapy photodynamic therapy chemistry Positron-Emission Tomography Drug delivery Nanoparticles Graphite HPPH optical imaging Research Paper |
| Zdroj: | Theranostics |
| ISSN: | 1838-7640 |
| DOI: | 10.7150/thno.8070 |
| Popis: | Graphene, a 2-dimensional carbon nanomaterial, has attracted wide attention in biomedical applications, owing to its intrinsic physical and chemical properties. In this work, a photosensitizer molecule, 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-alpha (HPPH or Photochlor®), is loaded onto polyethylene glycol (PEG)-functionalized graphene oxide (GO) via supramolecular π-π stacking. The obtained GO-PEG-HPPH complex shows high HPPH loading efficiency. The in vivo distribution and delivery were tracked by fluorescence imaging as well as positron emission tomography (PET) after radiolabeling of HPPH with (64)Cu. Compared with free HPPH, GO-PEG-HPPH offers dramatically improved photodynamic cancer cell killing efficacy due to the increased tumor delivery of HPPH. Our study identifies a role for graphene as a carrier of PDT agents to improve PDT efficacy and increase long-term survival following treatment. |
| Databáze: | OpenAIRE |
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