A Ring-D-Seco-Tetranortriterpenoid from Seeds of Carapa procera Active against Breast Cancer Cell Lines
| Autor: | Sophie Barillé-Nion, Aurélien Planchat, Gérald S. Remaud, Richard J. Robins, Steven Lohard, Matar Seck, Denis Loquet, Mbaye Diaw Dioum, Virginie Silvestre, Illa Tea |
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| Přispěvatelé: | Laboratoire de Chimie Organique et Thérapeutique, Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Bernardo, Elizabeth |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0106 biological sciences
Limonins Phytochemistry Ethyl acetate Pharmaceutical Science Breast Neoplasms [SDV.CAN]Life Sciences [q-bio]/Cancer Biology Limonoid 01 natural sciences Analytical Chemistry chemistry.chemical_compound [SDV.CAN] Life Sciences [q-bio]/Cancer Cell Line Tumor Drug Discovery Botany medicine Humans Meliaceae Cytotoxicity Carapa procera Tetranortriterpenoid Cell Proliferation Pharmacology Traditional medicine Molecular Structure 010405 organic chemistry Plant Extracts Organic Chemistry Carapa biology.organism_classification Antineoplastic Agents Phytogenic Triterpenes 3. Good health 0104 chemical sciences Complementary and alternative medicine chemistry Seeds Molecular Medicine Female Drug Screening Assays Antitumor 010606 plant biology & botany medicine.drug |
| Zdroj: | Planta Medica Planta Medica, Georg Thieme Verlag, 2016, ⟨10.1055/s-0042-107797⟩ Planta Medica, 2016, ⟨10.1055/s-0042-107797⟩ |
| ISSN: | 0032-0943 1439-0221 |
| DOI: | 10.1055/s-0042-107797⟩ |
| Popis: | The seeds of Carapa procera are exploited extensively in West African ethnopharmacy for the treatment of several pathologies, including inflammation. They also are effective as insect antifeedants and as a mosquito repellent. With the aim of identifying bioactive principles, an ethyl acetate extract of the defatted seeds was made and fractionated. Two principle compounds were isolated. One of these, 5,6-dehydro-7-deacetoxy- 7-oxogedunin (1), while known from another genus of the Meliaceae, is newly identified from the genus Carapa and its X‑ray structure is described for the first time. In addition, 1 displayed strong anti-clonogenic activity at 10 μM. The other compound, mexicanolide (2), is known from this species and showed neither cytotoxicity nor anticlonogenicity. These differences in efficacy are discussed in relation to known structure-activity relationships of limonoids. |
| Databáze: | OpenAIRE |
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