The effect of metastasis patterns on survival in male patients with different breast cancer subtypes: results from the Surveillance, Epidemiology, and End Results (SEER) database
| Autor: | Zeming Liu, Liang Guo, Min Wang, Shipei Wang, Wei Zhou, Yihui Huang, Chao Zhang, Sichao Chen, Wen Zeng, Wei Wei, Ling Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty business.industry Seer database Surveillance Epidemiology and End Results (SEER) Male breast cancer (MBC) medicine.disease breast cancer subtypes Metastasis Breast cancer Male patient Internal medicine Surveillance Epidemiology and End Results Medicine Original Article Radiology Nuclear Medicine and imaging prognosis metastasis pattern skin and connective tissue diseases business neoplasms |
| Zdroj: | Translational Cancer Research |
| ISSN: | 2219-6803 2218-676X |
| Popis: | Background Metastasis sites and breast cancer subtypes are important for breast cancer patients. This study aimed to assess possible relationships between them and their influence on prognosis in male breast cancer (MBC) patients. Methods We collected data on 2,983 patients with MBC from the Surveillance, Epidemiology, and End Results database, including 250 patients with M1 stage disease. Information on metastatic patterns was provided for bone, brain, liver, and lung metastases. MBC was classified into four subtypes: Her2−/HR+, Her2+/HR+, Her2+/HR−, and triple negative (TN). Univariate and multivariate logistic regression analysis were used to analyze the association, and Cox regression analyses were used to analyze prognosis. Results The bone was the most common metastatic site and the brain was the least common metastatic site. Patients with the Her2−/HR+ subtype had the highest proportion of metastatic disease, and Her2+/HR− patients had the lowest proportion. Univariate and multivariate logistic regression analyses showed that there were significant differences in distant metastasis patterns in patients with different subtypes. Men with the Her2+/HR+ or Her2−/HR+ subtypes with bone metastasis had better cancer specific survival (CSS), and those with the TN subtype had the worst CSS in all metastatic patterns. Conclusions MBC subtypes are associated with different metastasis patterns and can have different effects on prognosis. This study might provide insights into a better understanding of MBC. |
| Databáze: | OpenAIRE |
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