Selenium, a dietary-antioxidant with cardioprotective effects, prevents the impairments in heart rate and systolic blood pressure in adolescent rats exposed to binge drinking treatment
| Autor: | Olimpia Carreras, Paula Sobrino, María Del Carmen Gallego-Lopez, Fátima Nogales, M. Luisa Ojeda, Rui Manuel Rua |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant medicine.medical_treatment Medicine (miscellaneous) chemistry.chemical_element Binge drinking Blood Pressure Oxidative phosphorylation Antioxidants Binge Drinking chemistry.chemical_compound Selenium Heart Rate Internal medicine Heart rate medicine Animals Humans Rats Wistar business.industry Glutathione Rats Psychiatry and Mental health Clinical Psychology Oxidative Stress Endocrinology Blood pressure chemistry Liver Analysis of variance business |
| Zdroj: | The American journal of drug and alcohol abuse. 47(6) |
| ISSN: | 1097-9891 |
| Popis: | Background Binge drinking (BD) during adolescence is related to cardiovascular alterations. Selenium (Se) is an essential trace element with antioxidant, anti-inflammatory and antiapoptotic properties, essential for correct heart function. Objectives To study the protective cardiovascular effects of selenium in adolescent rats exposed to a BD-like procedure. Methods 32 adolescent male rats exposed to an intraperitoneally BD-like model or not, and supplemented with 0.4ppm of selenite or not, were divided into 4 groups: control, alcohol, control-selenium and alcohol-selenium. Blood pressure and heart rate (HR) were determined after experimentation. Se deposits, oxidative balance and the expression of glutathione peroxidases (GPxs), NF-kB and caspase-3 were measured in the heart. Also, DNA instability in rat lymphocytes and serum vascular markers were determined. Statistical analysis was performed with the ANOVA model. Results The BD-like model depleted Se heart deposits (p Conclusions Se supplementation presents cardioprotective effects since it reversed HR and systolic blood pressure observed in BD-exposed adolescent rats. |
| Databáze: | OpenAIRE |
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