Higher SARS-CoV-2 viral loads correlated with smaller thyroid volumes on ultrasound among male COVID-19 survivors
| Autor: | Ivan Hung, Carol H.Y. Fong, Wing Sun Chow, Connie Hong Nin Loong, Brian Hung-Hin Lang, Matrix Man Him Fung, Kelvin K. W. To, Alan Chun Hong Lee, Ching-Wan Lam, Polly Pang, Tip Yin Ho, Anthony Raymond Tam, David T W Lui, Cassandra Yuen Yan Lee, Chi Ho Lee, Wade Wei Wong, Karen S.L. Lam, Kathryn C.B. Tan, Keith Wan-Hang Chiu, Yu Cho Woo, Chun Yiu Law |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Thyroiditis endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Gastroenterology Thyroid function tests Endocrinology Internal medicine Diabetes mellitus medicine Humans Survivors Ultrasonography Thyroid gland medicine.diagnostic_test SARS-CoV-2 business.industry Thyroid COVID-19 Viral Load medicine.disease medicine.anatomical_structure Original Article Female Thyroid function business Viral load Body mass index Hormone |
| Zdroj: | Endocrine |
| ISSN: | 1559-0100 1355-008X |
| Popis: | Purpose Thyroid dysfunction, including thyroiditis, is well recognized in COVID-19 patients. We evaluated thyroid ultrasonographic features among COVID-19 survivors, which are less well known. Methods Adult COVID-19 survivors without known thyroid disorders who attended dedicated COVID-19 clinic underwent thyroid ultrasonography and assessment of thyroid function and autoimmunity. Adults admitted for acute non-thyroidal surgical problems and negative for COVID-19 were recruited as control. SARS-CoV-2 viral load (VL) was presented as the inverse of cycle threshold values from the real-time reverse transcription-polymerase chain reaction of the respiratory specimen on admission. Results In total, 79 COVID-19 patients and 44 non-COVID-19 controls were included. All abnormal thyroid function tests during acute COVID-19 recovered upon follow-up. Thyroid ultrasonography was performed at a median of 67 days after acute COVID-19. The median thyroid volume was 9.73 mL (IQR: 7.87–13.70). In multivariable linear regression, SARS-CoV-2 VL on presentation (standardized beta −0.206, p = 0.042) inversely correlated with thyroid volume, in addition to body mass index at the time of ultrasonography (p |
| Databáze: | OpenAIRE |
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