Cognitive decline in multiple sclerosis is related to the progression of retinal atrophy and presence of oligoclonal bands: a 5-year follow-up study
| Autor: | Egle Drukteiniene, Gintaras Kaubrys, A Cimbalas, Rasa Kizlaitiene, Rimvydas Asoklis, Natasa Giedraitiene |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
cognition medicine.medical_specialty genetic structures Nerve fiber layer multiple sclerosis BICAMS OCT oligoclonal bands brain atrophy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cerebrospinal fluid Atrophy Ophthalmology medicine Cognitive decline RC346-429 Original Research Third ventricle business.industry Multiple sclerosis Retinal medicine.disease 030104 developmental biology medicine.anatomical_structure chemistry Neurology Biomarker (medicine) Neurology (clinical) Neurology. Diseases of the nervous system business 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in neurology, Lausanne : Frontiers Media SA, 2021, vol. 12, art. no. 678735, p. [1-8] Frontiers in Neurology Frontiers in Neurology, Vol 12 (2021) |
| ISSN: | 1664-2295 |
| Popis: | Background: Brain atrophy, which is associated with cognitive impairment and retinal nerve fiber layer (RNFL) atrophy, is the main biomarker of neurodegeneration in multiple sclerosis (MS). However, data on the relationship between inflammatory markers, such as oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF), and cognition, RNFL atrophy, and brain atrophy are scarce. The aim of this study was to assess the influence of RNFL thickness, brain atrophy markers, intrathecal OCBs, and the immunoglobulin G (IgG) index on cognitive decline over a 5-year period in patients with MS.Methods: This prospective, single-center, observational cohort study included 49 patients with relapsing MS followed up over 5 years. At baseline, the patients underwent brain magnetic resonance imaging (MRI). Cognitive evaluation was performed using the Brief International Cognitive Assessment for MS (BICAMS), and RNFL thickness was assessed using optical coherence tomography (OCT). OCBs and IgG levels in the CSF were evaluated at baseline. The BICAMS, OCT, and MRI findings were re-evaluated after 5 years.Results: A significant reduction in information processing speed, visual learning, temporal RNFL thickness, the Huckman index, and third ventricle mean diameter was found in all 49 patients with relapsing MS over the observation period (p < 0.05). Of the patients, 63.3% had positive OCBs and 59.2% had elevated IgG indices. The atrophy of the temporal segment and papillomacular bundle and the presence of OCBs were significantly related to a decline in information processing speed in these patients (p < 0.05). However, brain atrophy markers were not found to be significant on the general linear models.Conclusions: RNFL atrophy and the presence of OCBs were related to cognitive decline in patients with MS over a 5-year follow-up period, thereby suggesting their utility as potential biomarkers of cognitive decline in MS. |
| Databáze: | OpenAIRE |
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