Direct Microtitre Plate Radioimmunoassay of Savoxepine in Unextracted Plasma
| Autor: | J. Godbillon, Luigi Botta, Gilbert Lefèvre, Martine Duval |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Guinea Pigs Immunology Radioimmunoassay Administration Oral Sensitivity and Specificity Plasma Microtiter plate Pharmacokinetics Animals Humans Biotransformation Pharmacology Savoxepine Reproducibility Chromatography Chemistry Microchemistry Extraction (chemistry) Reproducibility of Results Middle Aged Rats Dibenzoxazepines Schizophrenia Dopamine Antagonists Quantitative analysis (chemistry) Antipsychotic Agents |
| Zdroj: | Journal of Immunoassay. 17:29-46 |
| ISSN: | 0197-1522 |
| DOI: | 10.1080/01971529608005777 |
| Popis: | An original solid phase method for direct radioimmunoassay of the antipsychotic savoxepine (CGP 19,486 A) in plasma has been developed which does not require the extraction of the parent drug with organic solvents. The assay showed good reproducibility over the working concentration range 1.9-30.6 nmol/l with intra- and inter-assay coefficients of variationor = 16%. The procedure, which requires only small volumes of plasma (10 microliters), is simple to handle and well suited for routine analysis. The method allowed to investigate the pharmacokinetics of savoxepine in schizophrenic patients given low oral doses of the drug. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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