Mechanism of contrast enhancement in breast lesions at MR imaging
| Autor: | Adel Gad, U. Falkmer, B. Boné, M. Kristoffersen Wiberg, C. Parrado, Peter Aspelin |
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| Rok vydání: | 1998 |
| Předmět: |
Gadolinium DTPA
Pathology medicine.medical_specialty Contrast enhancement Cell index Contrast Media Breast Neoplasms Cell Count Benign tumours Diagnosis Differential Breast Diseases Random Allocation Parenchyma Humans Medicine Radiology Nuclear Medicine and imaging Breast Infusions Intravenous Image Cytometry Retrospective Studies Microvessel density Ploidies Radiological and Ultrasound Technology business.industry Carcinoma Breast tumours DNA Neoplasm General Medicine Image Enhancement Immunohistochemistry Magnetic Resonance Imaging Mr imaging Contrast medium Female business Cell Division |
| Zdroj: | Acta Radiologica. 39:494-500 |
| ISSN: | 0284-1851 |
| Popis: | Purpose: the aim of the study was to explain why breast lesions are enhanced by contrast medium at MR imaging and to elucidate the histopathological basis for the overlap in the enhancement patterns of benign and malignant breast lesions Material and Methods: Ten invasive breast carcinomas and 10 benign breast lesions were selected for the study. of the 10 carcinomas, 5 showed a strong and early contrast enhancement, and 5 did not. of the 10 benign lesions, 5 showed a strong and early contrast enhancement, and 5 showed no enhancement. the following morphometric variables were evaluated: proliferation cell index of neoplastic parenchymal cells, S-phase fraction, nuclear ploidy analysed by image DNA-cytometry, microvessel density, and the percentage proportion of the interstitial area Results: Contrast enhancement was related to the proliferating activity of the hyperplastic or neoplastic parenchymal cells and was inversely correlated with the interstitial area in carcinomas as well as in benign tumours and non-neo-plastic lesions of the breast Conclusion: Morphometric variables play an important role in the general mechanism of MR contrast enhancement in examinations of the breast and explain the histopathological basis for the overlap in the enhancement patterns of benign and malignant breast lesions |
| Databáze: | OpenAIRE |
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