The Antiacetylcholinesterase and Antileishmanial Activities ofCanarium patentinerviumMiq
| Autor: | Sukalyani Debnath, Achyut Adhikari, Banasri Hazra, R. Mogana, K. Teng-Jin, Christophe Wiart, Sudipta Hazra |
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| Rok vydání: | 2014 |
| Předmět: |
Rainforest
Article Subject Bioassay guided fractionation lcsh:Medicine General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Scopoletin Botany Humans Burseraceae Leishmaniasis IC50 Leishmania General Immunology and Microbiology Traditional medicine biology Plant Extracts lcsh:R Canarium patentinervium General Medicine Phenolic acid Syringic acid biology.organism_classification Plant Leaves Scoparone chemistry Acetylcholinesterase Cholinesterase Inhibitors Research Article |
| Zdroj: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | In continuation of our natural and medicinal research programme on tropical rainforest plants, a bioassay guided fractionation of ethanolic extract of leaves ofCanarium patentinerviumMiq. (Burseraceae Kunth.) led to the isolation of scopoletin(1), scoparone(2), (+)-catechin(3), vomifoliol(4), lioxin(5), and syringic acid(6). All the compounds exhibited antiacetylcholinesterase activity with syringic acid, a phenolic acid exhibiting good AChE inhibition (IC5029.53 ± 0.19 μg/mL). All compounds displayed moderate antileishmanial activity with scopoletin having the highest antileishmanial activity (IC50163.30 ± 0.32 μg/mL). Given the aforementioned evidence, it is tempting to speculate thatCanarium patentinerviumMiq. represents an exciting scaffold from which to develop leads for treatment of neurodegenerative and parasitic diseases. |
| Databáze: | OpenAIRE |
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