In Situ Tissue Engineering of the Bile Duct Using Polypropylene Mesh-Collagen Tubes
| Autor: | Akeo Hagiwara, Tatsuo Nakamura, Yuen Nakase, Tetsuji Yoshikawa, Kouji Miyagawa, Yoshiaki Kuriu, Chouhei Sakakura, Shingo Nakashima, Syuichi Kin, Hisakazu Yamagishi, Eigo Otsuji |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 030232 urology & nephrology Biomedical Engineering Medicine (miscellaneous) Bioengineering Polypropylenes Prosthesis Design Prosthesis Prosthesis Implantation Biomaterials 03 medical and health sciences Dogs 0302 clinical medicine Tissue engineering medicine Animals 030223 otorhinolaryngology Common Bile Duct Tissue Engineering Common bile duct business.industry Bile duct Regeneration (biology) Epithelial Cells General Medicine Surgery Polypropylene mesh medicine.anatomical_structure Collagen sponge Bile Ducts Collagen business Canine model |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.1177/039139880703000110 |
| Popis: | Multiple attempts have been made to replace biliary defects with a variety of materials. Recently, successful biliary reconstruction using the Gore-Tex vascular graft has been reported experimentally and clinically We designed a new artificial bile duct consisting of collagen sponge and polypropylene mesh. We presently evaluated the feasibility of using this prosthesis as a scaffold for bile duct tissue regeneration in a canine model. Our prosthesis, a sponge made from porcine dermal collagen, is reinforced with a polypropylene mesh cylinder. We used the prosthesis to reconstruct the middle portion of the common bile duct in seven beagle dogs to evaluate its efficacy. While one dog died of biliary stricture 8 months after operation, six survived without problems to scheduled time points for tissue evaluation at 1 to 12 months. All prostheses had become completely incorporated into the host. A confluent epithelial lining was observed within 3 months. In cholangiograms the prosthesis displayed long-term patency in the six dogs and provided satisfactory bile drainage for up to 12 months. Our graft thus shows promise for repair of biliary defects and should lead to development of a new treatment for biliary reconstruction. |
| Databáze: | OpenAIRE |
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