Brazilian Journal of Infectious Diseases
| Autor: | Braga Eduardo Lorens, Lyra André Castro, Ney-Oliveira Fabrizio, Nascimento Lourianne, Silva Adriano, Brites Carlos, Marbak Rosicreuza, Lyra Luiz Guilherme Costa, Ribeiro Neto Manuel L., Shah Koonj Asvin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Liver Cirrhosis Male Microbiology (medical) medicine.medical_specialty Cirrhosis Adolescent Genotype Hepatitis C virus clinical course lcsh:QR1-502 HIV Infections Hepacivirus medicine.disease_cause Chronic liver disease Severity of Illness Index lcsh:Microbiology Group B lcsh:Infectious and parasitic diseases Liver disease co-infection Clinical course Risk Factors Antiretroviral Therapy Highly Active Internal medicine Prevalence medicine Humans lcsh:RC109-216 Hepatitis B virus Hepatitis business.industry virus diseases HIV Hepatitis C Hepatitis C Chronic medicine.disease Co-infection Cross-Sectional Studies Infectious Diseases HCV genotype Immunology Disease Progression Female business Brazil |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA Brazilian Journal of Infectious Diseases, Volume: 10, Issue: 1, Pages: 17-21, Published: FEB 2006 Brazilian Journal of Infectious Diseases v.10 n.1 2006 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Vol 10, Iss 1, Pp 17-21 |
| DOI: | 10.1590/S1413-86702006000100004 |
| Popis: | Texto completo: acesso restrito. p.17-21 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-09-03T14:45:17Z No. of bitstreams: 1 a04v10n1.pdf: 40671 bytes, checksum: a5941834761ed04d40e0319bdcad047c (MD5) Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-09-16T17:38:54Z (GMT) No. of bitstreams: 1 a04v10n1.pdf: 40671 bytes, checksum: a5941834761ed04d40e0319bdcad047c (MD5) Made available in DSpace on 2013-09-16T17:38:54Z (GMT). No. of bitstreams: 1 a04v10n1.pdf: 40671 bytes, checksum: a5941834761ed04d40e0319bdcad047c (MD5) Previous issue date: 2006 Co-infection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is increasingly common and affects the clinical course of chronic hepatitis C. Highly active antiretroviral therapy has improved the life expectancy of HIV infected patients, but, by extending survival, it permits the development of HCV cirrhosis. This study tried to evaluate clinical and epidemiological features of patients with chronic hepatitis C co-infected with HIV. We evaluated 134 HCV-infected patients: i) group A – 65 co-infected HCV/HIV patients, ii) group B – 69 mono-infected HCV patients. The impact of HIV infection on HCV liver disease was analyzed using Child's score, ultrasound findings and liver histology. Patients were subjected to HCV genotyping and anti-HBs dosage. Patients mean age was 42.4 years (±9.1) and 97 (72.4%) were males. Injected drug use and homo/bisexual practice were more frequently encountered in the co-infected group: 68.3% and 78.0%, respectively. Antibodies against hepatitis B virus (anti-HBs) were found in only 38.1% of the patients (66.7% group A x 33.3% group B). Ten out of 14 individuals (71.4%) who had liver disease (Child B or C) and 25 out of 34 (73.5%) who showed ultrasound evidence of chronic liver disease were in the co-infection group. HCV genotype-2/3 was more frequently encountered in co-infected patients (36.9% group A vs. 21.8% group B). Conclusions: a) HIV infection seems to adversely affect the clinical course of chronic hepatitis C, b) injected drug use, bi/homosexual practice and genotype-2/3 were more frequently encountered in co-infected patients, c) immunization against HBV should be encouraged in these patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|