Familial hypophosphataemic rickets: experience with 24 children from Kuwait
| Autor: | F. A. Khuffash, T. S. Al-Shab, D. C. Sharda, P. C. Reavey, M. M. Lubani |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent 030231 tropical medicine Rickets Disease Phosphates Nutritional Rickets 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Humans Prospective Studies Child Hypophosphatemia Familial Bone Development Hydroxycholecalciferols business.industry Final height Infant Familial hypophosphataemic rickets Serum phosphate medicine.disease Hypophosphatemic Rickets Kuwait El Niño Child Preschool Pediatrics Perinatology and Child Health Calcium Drug Therapy Combination Female business |
| Zdroj: | Annals of Tropical Paediatrics. 10:377-381 |
| ISSN: | 1465-3281 0272-4936 |
| DOI: | 10.1080/02724936.1990.11747461 |
| Popis: | Between 1982 and 1988, familial hypophosphataemic rickets (FHR) was diagnosed in 24 children, in nine during screening of the families of index patients. The average annual incidence was 0.2/1000 live births. There were 16 boys and 8 girls in 10 families, of which nine had more than one affected child. Their ages at the onset of the disease ranged between 10 months and 14 years (mean 6.9 yrs). Growth retardation and bowing of the legs were the most prominent features, observed in all index patients and in four of the patients diagnosed by screening. Treatment with 1 alpha-hydroxyvitamin D3 and phosphates was associated with acceleration of growth in all children, healing of rickets in 21, and normalization of the serum phosphate in 22. Two children with late diagnosis are now older than 16 years with a final height below the 3rd centile. Three more pubertal children are also shorter than the 3rd centile. In areas where nutritional rickets is common, FHR is likely to be missed and the treatment delayed with grave consequences; in particular, growth retardation and bone deformity. |
| Databáze: | OpenAIRE |
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