Circulating endothelial progenitor cells in pregnant women with premature rupture of membranes: potential association with placental disorders
| Autor: | Masoumeh Esmaeilivand, Azam Sharifi, Masoumeh Jabarpour, Simin Asadian, Pirouz Pourmohammad, Vahid Siavashi, Seyed Mahdi Nassiri |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Vascular Endothelial Growth Factor A Fetal Membranes Premature Rupture Placental disorders Placenta Diseases Prom Reproductive technology Biology Andrology 03 medical and health sciences 0302 clinical medicine Endocrinology Cell Movement Pregnancy Genetics medicine Humans Secretion 030212 general & internal medicine Progenitor cell Molecular Biology Oestrogen receptor α Cell Proliferation Endothelial Progenitor Cells Estrogens medicine.disease Chemokine CXCL12 030104 developmental biology Reproductive Medicine Animal Science and Zoology Female Premature rupture of membranes Developmental Biology Biotechnology |
| Zdroj: | Reproduction, fertility, and development. 30(12) |
| ISSN: | 1031-3613 |
| Popis: | The frequency of preterm labour has risen over the last few years. Plasma oestrogen concentrations differ between patients who deliver before term and those who deliver at term. Oestrogen can influence the kinetics of circulating endothelial progenitor cells (cEPCs). Here, we attempted to identify the potential association of cEPCs with the incidence of complications typical of prematurity. The study groups consisted of 60 pregnant women with premature rupture of membranes (PROM; less than 37 weeks) and 50 term pregnant women (more than 38 weeks). cEPCs were isolated from term pregnant women and pregnant women with PROM and then migratory, proliferative, tubulogenic and functional properties of these cells along with serum secretion of important EPC chemotactic cytokines were analysed. In addition, the effect of 17β-oestradiol on biological features of cEPCs harvested from pregnant women was investigated. Our results showed that an increased concentration of oestrogen in women with PROM was associated with increased numbers of cEPCs, with these cells having increased oestrogen receptor α expression together with augmented proliferative, migratory and colony-formation properties. 17β-oestradiol induced proliferation, migration and angiogenic secretory activity of cEPCs from pregnant women. Overall, circulation mobilisation of EPCs in pregnant women may be associated with placental disorders. |
| Databáze: | OpenAIRE |
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