Increase of bikunin and alpha1-microglobulin concentrations in urine of rats during pregnancy is due to decreased tubular reabsorption
| Autor: | Ulf J Eriksson, Erika Fries, Cecilia Falkenberg, Anna M. Blom, Bo Åkerström, Mats Sjöquist |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Orosomucoid Urine Bikunin Rats Sprague-Dawley Pregnancy Internal medicine Alpha-Globulins medicine Animals RNA Messenger Molecular Biology Glycoproteins Membrane Glycoproteins biology Beta-2 microglobulin Chemistry Reabsorption Albumin α1-microglobulin medicine.disease Blood proteins Rats Endocrinology Kidney Tubules Liver Renal physiology biology.protein Molecular Medicine Female Trypsin Inhibitor Kunitz Soybean |
| Zdroj: | Biochimica et biophysica acta. 1361(2) |
| ISSN: | 0006-3002 |
| Popis: | Bikunin and alpha1-microglobulin are two plasma proteins of about 25 kDa which are made in the liver from a common precursor. The concentration of bikunin in human urine has been shown to increase several fold during various conditions of stress. The mechanism behind this increase is unknown. We have studied pregnant rats and found that the bikunin and alpha1-microglobulin levels in their urine increased 3-fold towards the end of the pregnancy, whereas those of albumin and orosomucoid did not. There were no significant changes in either the bikunin/alpha1-microglobulin mRNA level or the concentrations of the two proteins in serum. These findings imply that the synthesis and the clearance rates of bikunin and alpha1-microglobulin are normal during pregnancy but that the tubular reabsorption of these proteins is decreased. |
| Databáze: | OpenAIRE |
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