Changes in Renal Prostanoid Synthesis Induced by Potassium Loading in Rats
| Autor: | Jacques Bernheim, Eduardo Podjarny, N. Kariv, Mauro Rathaus, Israel Arber, J. Shapira |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Sodium Potassium chemistry.chemical_element Alpha (ethology) 6-Ketoprostaglandin F1 alpha Dinoprost Kidney Dinoprostone Excretion chemistry.chemical_compound Internal medicine medicine Animals Homeostasis business.industry Rats Thromboxane B2 Endocrinology medicine.anatomical_structure chemistry Prostaglandins Female lipids (amino acids peptides and proteins) business circulatory and respiratory physiology |
| Zdroj: | Nephron. 51:540-543 |
| ISSN: | 2235-3186 1660-8151 |
| DOI: | 10.1159/000185390 |
| Popis: | Previous works have demonstrated changes in the urinary excretion of prostaglandins (PG) in response to changes in potassium (K) or sodium (Na) intake. In the present study, the production of PGE2, PGF2 alpha, 6-keto-PGF1 alpha and thromboxane B2 (TXB2) by isolated glomeruli, cortical homogenates, medullary and papillary slices was measured in K-loaded rats on either a normal or a low Na intake. In glomeruli, K loading increased selectively PGE2 synthesis. In Na-depleted animals, all prostanoids were elevated and K loading did not induce a further increase. In cortical and medullary preparations, PGE2 was decreased by K loading irrespective of the state of Na balance. In papilla, PGE2 decreased (in all K-loaded rats) and PGF2 alpha increased (only in rats with normal Na intake). 6-Keto-PGF1 alpha and TXB2 did not change significantly. No correlation was present between changes of PG synthesis and urinary kallikrein excretion. The results demonstrate a specific effect of K on PGE2 and PGF2 alpha, and suggest a role for these substances in K homeOstasis. |
| Databáze: | OpenAIRE |
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