Inhibitors of Angiogenesis
| Autor: | U. T. Hacker, H. Büning |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
business.industry Angiogenesis Genetic enhancement Cancer Macular degeneration Angiogenic Proteins medicine.disease Blockade 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system 030220 oncology & carcinogenesis Cancer research Medicine Receptor business |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9783319328041 Protein Targeting Compounds ISBN: 9783319224725 |
| Popis: | Angiogenesis plays a pivotal role in malignant, ischemic, inflammatory, infectious and immune disorders. The increasing molecular understanding of angiogenic processes fostered the development of strategies to induce or inhibit angiogenesis for therapeutic purposes. Here, we focus on anti-angiogenic therapies, which represent a standard of care in the treatment of different cancer types and in neovascular age-related macular degeneration. Specifically, strategies related to the blockade of angiogenic proteins and receptors will be outlined covering both preclinical and clinical aspects. Finally, examples of gene therapy based anti-angiogenic approaches are presented. |
| Databáze: | OpenAIRE |
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