The effects of stenting on coronary endothelium from a molecular biological view: Time for improvement?

Autor: Anne Cornelissen, Felix Vogt
Rok vydání: 2018
Předmět:
0301 basic medicine
medicine.medical_specialty
Endothelium
pro‐healing stents
medicine.medical_treatment
Myocytes
Smooth Muscle
Review
Constriction
Pathologic
Revascularization
Balloon
restenosis
03 medical and health sciences
0302 clinical medicine
endothelial function
Restenosis
Internal medicine
Angioplasty
coronary stents
medicine
endothelial denudation
Animals
Humans
cardiovascular diseases
Angioplasty
Balloon
Coronary
Progenitor cell
Cell Proliferation
stent thrombosis
business.industry
Coronary Stenosis
Endothelial Cells
(re‐) endothelialization
Cell Biology
equipment and supplies
medicine.disease
Thrombosis
surgical procedures
operative
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cardiology
Molecular Medicine
Stents
Endothelium
Vascular
business
Artery
Zdroj: Journal of Cellular and Molecular Medicine
ISSN: 1582-1838
DOI: 10.1111/jcmm.13936
Popis: Coronary artery stenting following balloon angioplasty represents the gold standard in revascularization of coronary artery stenoses. However, stent deployment as well as percutaneous transluminal coronary angioplasty (PTCA) alone causes severe injury of vascular endothelium. The damaged endothelium is intrinsically repaired by locally derived endothelial cells and by circulating endothelial progenitor cells from the blood, leading to re‐population of the denuded regions within several weeks to months. However, the process of re‐endothelialization is often incomplete or dysfunctional, promoting in‐stent thrombosis and restenosis. The molecular and biomechanical mechanisms that influence the process of re‐endothelialization in stented segments are incompletely understood. Once the endothelium is restored, endothelial function might still be impaired. Several strategies have been followed to improve endothelial function after coronary stenting. In this review, the effects of stenting on coronary endothelium are outlined and current and future strategies to improve endothelial function after stent deployment are discussed.
Databáze: OpenAIRE
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