Delivering therapeutic cannabinoids via skin: Current state and future perspectives
| Autor: | Umeh I. Chukwunyere, Divya Thakur, Akeemat O. Tijani, Dhruv Mishra, Dorcas Frempong, Ashana Puri |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
medicine.medical_specialty media_common.quotation_subject Biological Availability Pharmaceutical Science 02 engineering and technology 03 medical and health sciences High doses Cannabidiol Medicine Dronabinol Medical prescription Intensive care medicine Cannabis 030304 developmental biology media_common Transdermal 0303 health sciences biology Cannabinoids business.industry 021001 nanoscience & nanotechnology biology.organism_classification Drug delivery Research studies 0210 nano-technology business medicine.drug |
| Zdroj: | Journal of Controlled Release. 334:427-451 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/j.jconrel.2021.05.005 |
| Popis: | Adequate evidence exists in the literature indicating a relatively positive shift with regards to the legal acceptance of cannabis and cannabis-derived products for medicinal purposes in some countries. Concomitantly, scientists are showing renewed interest in cannabis-related research work. Over the years, clinical and preclinical studies have demonstrated the therapeutic significance of cannabinoids for diverse indications. Additionally, efforts are being made to develop cannabis-related products into acceptable prescription products. FDA authorization for the commercial use of four cannabinoid-derived products, available as oral dosage forms is a significant progress already. However, there are certain drawbacks associated with the conventional delivery forms of cannabinoids. These include low oral bioavailability due to hepatic degradation, gastric instability, poor water solubility, and the side effects experienced upon the use of high doses of psychotropic cannabinoids associated with heightened plasma concentrations of the drug. These are however, limitable with the aid of transcutaneous drug delivery. Emerging topical and transdermal strategies could be exploited for the successful development of highly effective delivery systems for cannabinoids. This review discusses the feasibility of delivering therapeutic cannabinoids via skin and provides a comprehensive account of the supporting research studies that have been reported in the literature till date. |
| Databáze: | OpenAIRE |
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