Re-Irradiation in Patients with Recurrent Rectal Cancer is Safe and Feasible
| Autor: | Boudewijn van Etten, Esmée A Dijkstra, Geke A. P. Hospers, Klaas Havenga, Christina T. Muijs, Veronique E.M. Mul, Patrick H. J. Hemmer |
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| Přispěvatelé: | Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Robotics and image-guided minimally-invasive surgery (ROBOTICS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Re-Irradiation
medicine.medical_specialty Colorectal cancer medicine.medical_treatment Gastroenterology Capecitabine Surgical oncology Internal medicine medicine Humans Pathological Neoplasm Staging Retrospective Studies Colorectal Cancer Salvage Therapy business.industry Rectal Neoplasms Rectum Chemoradiotherapy medicine.disease Neoadjuvant Therapy Radiation therapy Treatment Outcome Oncology Toxicity Surgery Neoplasm Recurrence Local business medicine.drug |
| Zdroj: | Annals of Surgical Oncology, 28, 5194-5204. SPRINGER Annals of Surgical Oncology |
| ISSN: | 1068-9265 |
| Popis: | Background There is no consensus yet for the best treatment regimen in patients with recurrent rectal cancer (RRC). This study aims to evaluate toxicity and oncological outcomes after re-irradiation in patients with RRC in our center. Clinical (cCR) and pathological complete response (pCR) rates and radicality were also studied. Methods Between January 2010 and December 2018, 61 locally advanced RRC patients were treated and analyzed retrospectively. Patients received radiotherapy at a dose of 30.0–30.6 Gy (reCRT) or 50.0–50.4 Gy chemoradiotherapy (CRT) in cases of no prior irradiation because of low-risk primary rectal cancer. In both groups, patients received capecitabine concomitantly. Results In total, 60 patients received the prescribed neoadjuvant (chemo)radiotherapy followed by surgery, 35 patients (58.3%) in the reRCT group and 25 patients (41.7%) in the long-course CRT group. There were no significant differences in overall survival (p = 0.82), disease-free survival (p = 0.63), and local recurrence-free survival (p = 0.17) between the groups. Patients in the long-course CRT group reported more skin toxicity after radiotherapy (p = 0.040). No differences were observed in late toxicity. In the long-course CRT group, a significantly higher cCR rate was observed (p = 0.029); however, there was no difference in the pCR rate (p = 0.66). Conclusions The treatment of RRC patients with re-irradiation is comparable to treatment with long-course CRT regarding toxicity and oncological outcomes. In the reCRT group, less cCR was observed, although there was no difference in pCR. The findings in this study suggest that it is safe and feasible to re-irradiate RRC patients. |
| Databáze: | OpenAIRE |
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