Sonochemical route for mesoporous silica-coated magnetic nanoparticles towards pH-triggered drug delivery system
| Autor: | Carlos E. de Castro, M. R. Ibarra, Fernando C. Giacomelli, Gerardo F. Goya, J. J. Bonvent, Alex Carvalho Alavarse, Jesús Antonio Fuentes-García |
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| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Fundações de Amparo à Pesquisa (Brasil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Release kinetics
Mining engineering. Metallurgy Materials science Kinetics TN1-997 Metals and Alloys Gompertz model Mesoporous silica Hemocompatibility assay Surfaces Coatings and Films Nanomaterials Biomaterials Chemical engineering Drug delivery Ceramics and Composites Magnetic nanoparticles Magnetic hyperthermia Hybrid material Mesoporous material Dissolution Sonochemistry |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Journal of Materials Research and Technology, Vol 15, Iss, Pp 52-67 (2021) |
| Popis: | This work reports a pH-triggered release system based on core@shell mesoporous magnetic nanoparticles (MNP@mSiO2) obtained using a simple and rapid ultrasound-assisted method. Performed characterization reveals magnetic cores of Fe2.9Mn0.1O4 (38 ± 6 nm) and specific loss power values adequate for hyperthermia (463 W/g), surrounded by a mesoporous silica shell (10 ± 2 nm) with large surface area (269 m2 g-1) functionalized with hydroxyl groups (-OH). MNP@mSiO2 were loaded with DOX and amino-silane grops, providing pH-triggered DOX release at acidic environments, driving by dipolar intermolecular interactions. The experimental DOX release kinetics at pH 5.5, 6.6 and 7.4 were determined and adjusted to Gompertz dissolution model (Nash–Sutcliffe efficiency coefficient (NSE>0.9)), where the only strongly pH-dependent variable is the percentage of DOX released. The pH-triggered response observed in the system was ~20% of the DOX loaded into the MNP@mSiO2 is released at pH 6.6 or 7.4, whereas up to 80 wt% is released at pH 5.5. Time to 50% of release and dissociation rate of the system remaining constant, suggesting no-pH influence on these parameters. The biological assays highlight negligible hemolytic effect and cytocompatibility of the hybrid material, pointing out the potential use of MNP@mSiO2 as a magnetic driven drug delivery system with pH-triggered drug release kinetics at acidic environments. These results probe the feasibility of sonochemical methods in the elaboration of biocompatible and controlled properties nanomaterials for drug release applications, with the advantage of accurately responses predictions by mathematical model and using minimal processing steps or laboratory equipment. This work was partially supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (project PID2019-106947RB-C21), FAPESP, Brazil (Grant 2014/50983-3) and CAPES, Brazil (Grant 88881.189090/2018-01). FCG acknowledges the financial support provided by FAPESP (Grant 2019/06634-8). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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