Akirin proteins in development and disease: critical roles and mechanisms of action
| Autor: | Stacey L. Peek, Joshua A. Weiner, Sarit Smolikove, Peter J. Bosch |
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| Rok vydání: | 2020 |
| Předmět: |
Computational biology
Biology Muscle Development medicine.disease_cause Article Chromatin remodeling Cellular and Molecular Neuroscience Neoplasms Gene expression medicine Animals Humans Nuclear protein Molecular Biology Transcription factor Gene Adaptor Proteins Signal Transducing Cell Proliferation Pharmacology Cell Cycle Brain Nuclear Proteins Cell Biology DNA-Binding Proteins Gene Expression Regulation Molecular Medicine Signal transduction Carcinogenesis Function (biology) Signal Transduction Transcription Factors |
| Zdroj: | Cell Mol Life Sci |
| ISSN: | 1420-9071 1420-682X |
| DOI: | 10.1007/s00018-020-03531-w |
| Popis: | The Akirin genes, which encode small, nuclear proteins, were first characterized in 2008 in Drosophila and rodents. Early studies demonstrated important roles in immune responses and tumorigenesis, which subsequent work found to be highly conserved. More recently, a multiplicity of Akirin functions, and the associated molecular mechanisms involved, have been uncovered. Here, we comprehensively review what is known about invertebrate Akirin and its two vertebrate homologues Akirin1 and Akirin2, highlighting their role in regulating gene expression changes across a number of biological systems. We detail essential roles for Akirin family proteins in the development of the brain, limb, and muscle, in meiosis, and in tumorigenesis, emphasizing associated signaling pathways. We describe data supporting the hypothesis that Akirins act as a “bridge” between a variety of transcription factors and major chromatin remodeling complexes, and discuss several important questions remaining to be addressed. In little more than a decade, Akirin proteins have gone from being completely unknown to being increasingly recognized as evolutionarily conserved mediators of gene expression programs essential for the formation and function of animals. |
| Databáze: | OpenAIRE |
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