A retrospective study on a cohort of patients with lymphocytic colitis
| Autor: | S. Reggiani, Rinaldo Pellicano, A G Bonagura, F Pallavicino, C Sguazzini, A La Terra, Marco Astegiano, Ezio David, D Simondi, M. Rizzetto |
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| Rok vydání: | 2010 |
| Předmět: |
Budesonide
Adult Colitis Lymphocytic Male Diarrhea medicine.medical_specialty Abdominal pain Lymphocytic colitis Adolescent Microscopic colitis Gastroenterology chemistry.chemical_compound Young Adult Mesalazine Internal medicine medicine Humans Colitis Aged Retrospective Studies Aged 80 and over Collagenous colitis business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease chemistry Female medicine.symptom business medicine.drug |
| Zdroj: | Revista Española de Enfermedades Digestivas v.102 n.6 2010 SciELO España. Revistas Científicas Españolas de Ciencias de la Salud instname |
| Popis: | Objective: the term “microscopic colitis” includes lymphocyt ic colitis (LC) and collagenous colitis, bearing common clinical pre sentation distinguishable only by histopathological examination of colonic biopsies. This study reports on demographic and clinical characteristics, and outcome of a cohort of patients with LC. Methods: demographic, clinical and histopathological data were reviewed. Every patient underwent total colonoscopy with multiple biopsies examined by an expert pathologist. Diagnosis of LC was confirmed if histopathological criteria were present. Rou tine laboratory tests were collected to rule out other diagnosis. Results: we included 80 patients (28 males; mean age: 46.4 years). At diagnosis, 71 patients (88%) reported diarrhea, 46 (58%) abdominal pain, 21 (36%) weight loss, 10 (13%) nausea. Regarding autoimmune or inflammatory diseases accompanying LC, thyroid disorders and celiac disease (CD) ranked first. More over, in over 10% of patients who underwent esophagogastro duodenoscopy, duodenal biopsies showed villi alterations classified as Marsh I damage, without clinical and serological data for diag nosis of CD. Mesalazine and oral topical steroids (budesonide or beclomethasone) were used to treat LC in 34 (43%) and 32 (39%) of patients, respectively, with similar percentages of clinical re sponse (approximately 80%). Conclusions: the need for total colonoscopy with multiple biopsies in all patients with chronic watery diarrhea was con firmed. Since the association between CD and LC exists, addition al tests should be performed in patients not responding to glutenfree diet or to LC specific therapy to exclude the other condition. Mesalazine obtained a similar outcome than oral steroids in this cohort. |
| Databáze: | OpenAIRE |
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