Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study
Autor: | Stefano Rosso, Roberto Zanetti, Klaus J. Busam, Hoda Anton-Culver, Bruce K. Armstrong, Peter A. Kanetsky, Anne Kricker, Loraine D. Marrett, Nancy E. Thomas, Pampa Roy, Terence Dwyer, Li Luo, Susan Paine, Stephen B. Gruber, Marianne Berwick, Colin B. Begg, Richard P. Gallagher, Anne S. Reiner, Irene Orlow |
---|---|
Rok vydání: | 2015 |
Předmět: |
Male
0301 basic medicine Oncology Canada Cancer Research medicine.medical_specialty Skin Neoplasms Genotype TaqI Population Original Manuscript Single-nucleotide polymorphism Polymorphism Single Nucleotide Calcitriol receptor 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans education Melanoma Proportional Hazards Models education.field_of_study business.industry Proportional hazards model Australia General Medicine medicine.disease United States 030104 developmental biology Haplotypes Italy Vitamin D3 Receptor chemistry 030220 oncology & carcinogenesis Immunology Cutaneous melanoma Receptors Calcitriol Female business |
Zdroj: | Carcinogenesis. 37:30-38 |
ISSN: | 1460-2180 0143-3334 |
DOI: | 10.1093/carcin/bgv157 |
Popis: | Factors known to affect melanoma survival include age at presentation, sex and tumor characteristics. Polymorphisms also appear to modulate survival following diagnosis. Result from other studies suggest that vitamin D receptor (VDR) polymorphisms (SNPs) impact survival in patients with glioma, renal cell carcinoma, lung, breast, prostate and other cancers; however, a comprehensive study of VDR polymorphisms and melanoma-specific survival is lacking. We aimed to investigate whether VDR genetic variation influences survival in patients with cutaneous melanoma. The analysis involved 3566 incident single and multiple primary melanoma cases enrolled in the international population-based Genes, Environment, and Melanoma Study. Melanoma-specific survival outcomes were calculated for each of 38 VDR SNPs using a competing risk analysis after adjustment for covariates. There were 254 (7.1%) deaths due to melanoma during the median 7.6 years follow-up period. VDR SNPs rs7299460, rs3782905, rs2239182, rs12370156, rs2238140, rs7305032, rs1544410 (BsmI) and rs731236 (TaqI) each had a statistically significant (trend P values < 0.05) association with melanoma-specific survival in multivariate analysis. One functional SNP (rs2239182) remained significant after adjustment for multiple testing using the Monte Carlo method. None of the SNPs associated with survival were significantly associated with Breslow thickness, ulceration or mitosis. These results suggest that the VDR gene may influence survival from melanoma, although the mechanism by which VDR exerts its effect does not seem driven by tumor aggressiveness. Further investigations are needed to confirm our results and to understand the relationship between VDR and survival in the combined context of tumor and host characteristics. |
Databáze: | OpenAIRE |
Externí odkaz: |