Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination
| Autor: | Michael Wegner, C. Claus Stolt |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
SOX10 Schwann cell Context (language use) Biology 03 medical and health sciences Myelin medicine Animals Molecular Biology Transcription factor Myelin Sheath General Neuroscience Gene Expression Regulation Developmental Neural crest Biological Evolution 030104 developmental biology medicine.anatomical_structure nervous system Neofunctionalization Schwann Cells Neurology (clinical) Neuroscience Function (biology) Transcription Factors Developmental Biology |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2015.09.025 |
| Popis: | As derivatives of the neural crest, Schwann cells represent a vertebrate invention. Their development and differentiation is under control of a newly constructed, vertebrate-specific regulatory network that contains Sox10, Oct6 and Krox20 as cornerstones and central regulators of peripheral myelination. In this review, we discuss the function and relationship of these transcription factors among each other and in the context of their regulatory network, and present ideas of how neofunctionalization may have helped to recruit them to their novel task in Schwann cells. This article is part of a Special Issue entitled SI: Myelin Evolution. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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