Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C
| Autor: | Kun Chen, Lai Wei, Shi-Gan Ling, Huiying Rao, Cuixia Zhu, Xiao-Guo Song, Xiaoyan Feng, Xiang-Ying Zhang, Jing He, Heqiu Zhang, Bingshui Xiu, Guohua Wang |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cirrhosis Brief Article viruses Hepatitis C virus Molecular Sequence Data Protein Array Analysis Cross Reactions medicine.disease_cause Asymptomatic Virus Viral Proteins Liver disease medicine Humans Amino Acid Sequence Hepatitis biology business.industry Gastroenterology virus diseases General Medicine Hepatitis C Hepatitis C Antibodies Hepatitis C Chronic Middle Aged medicine.disease digestive system diseases Antibody Formation Immunology biology.protein Female medicine.symptom Antibody business Sequence Alignment |
| Zdroj: | World Journal of Gastroenterology. 16:4460 |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v16.i35.4460 |
| Popis: | AIM: To evaluate the presence and cross-reactive antibodies against hypervariable region 1 (HVR1) in hepatitis C virus (HCV) infected patients and its relationship with the progression of the disease. METHODS: Sixteen representative HVR1 proteins selected from a unique set of 1600 natural sequences were used to semiquantitate the cross-reactivity of HVR1 antibodies in the sera of HCV patients. Fifty-five chronic HCV patients including 23 with asymptomatic mild hepatitis, 18 with chronic hepatitis and 16 with liver cirrhosis patients were studied. RESULTS: The degree of the cross-reactivity of anti-HVR1 antibodies in 23 patients with mild asymptomatic hepatitis was 3.09 ± 2.68, which was significantly lower than in those with chronic hepatitis (5.44 ± 3.93, P < 0.05) and liver cirrhosis (7.44 ± 3.90, P < 0.01). No correlation was observed between the broadness of the cross-reactivity anti-HVR1 antibodies and patient’s age, infection time, serum alanine aminotransferase activity, or serum HCV-RNA concentration. It was the breath of cross-reactivity rather than the presence of anti-HVR1 antibody in HCV sera that was associated with the progression of liver disease. CONCLUSION: The broadly cross-reactive HVR1 antibodies generated in natural HCV patients can not neutralize the virus, which results in persistent infection in patients with chronic hepatitis. |
| Databáze: | OpenAIRE |
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