MGMT mRNA expression predicts clinical outcome in malignant glioma after radiotherapy and/or chemotherapy independent of MGMT promoter methylation

Autor:	Thon, N, Kreth, S, Eigenbrod, S, Kretzschmar, H, Tonn, JC, Kreth, FW
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	ddc: 610 610 Medical sciences Medicine neoplasms
Zdroj:	61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010; 20100921-20100925; Mannheim; DOCV1536 /20100916/
DOI:	10.3205/10dgnc013
Popis:	Objective: Epigenetic silencing of the gene that encodes for O6-Methylguanine-DNA-methyltransferase (MGMT) has been correlated with favourable clinical outcome in patients with malignant gliomas after radio-/chemotherapy using alkylating agents such as temozolomide; It has been hypothesized that[for full text, please go to the a.m. URL] 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010
Databáze:	OpenAIRE
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